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alpha-Carbamoylsulfides as N-Carbamoylimine Precursors in the Visible Light Photoredox-Catalyzed Synthesis of alpha,alpha-Disubstituted Amines

Lebee, C; Languet, M; Allain, C; Masson, G ORGANIC LETTERS 2016, 18, 1478-1481.

A general and practical photoredox-promoted addition of nucleophiles to N-acylimines generated in situ from alpha-amidosulfides using Ru(bpy)(3)(PF6)(2) as the photocatalyst is reported. The broad scope of the reaction toward various nucleophiles and amidosulfide derivatives was explored. This novel protocol provides a rapid, mild, and efficient access to valuable alpha,alpha-disubstituted amines in respectable yields.

Type :

Publication

Dates :

Paru le 7 mars 2016

Informations complémentaires :

DOI: 10.1021/acs.orglett.6b00442