Accueil > Recherche > Publications / brevets > Publications équipe ENSEMBLE > Publications Moléc nanomat fluo

Recherche - Valorisation

Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging

Decuypere, E; Riomet, M; Sallustrau, A; Bregant, S; Thai, R; Pieters, G; Clavier, G; Audisio, D; Taran, F, Chemical Communications, 2018, 24, 10758-10761.

Copper-catalyzed and copper-free sydnone–alkyne cycloaddition reactions have emerged as complementary click tools for chemical biology but their use in bioorthogonal labeling is still in its infancy. Herein, combinations of alkynes and coumarin-sydnones were screened for their ability to generate pyrazole products displaying strong fluoroscence enhancement compared to reactants. One sydnone was identified as a particularly suitable new turn-on probe for protein labeling.

Type :

Publication

Dates :

Paru le 28 septembre 2018

Informations complémentaires :

DOI: 10.1039/c8cc06070c