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Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: Novel construction of PTP1B inhibitors on a sugar scaffold

C. Li, X. P. He, Y. J. Zhang, Z. Li, L. X. Gao, X. X. Shi, J. Xie, J. Li, G. R. Chen and Y. Tang Eur. J. Med. Chem., 2011, 46, 9, 4212-4218

With an aim of developing novel protein tyrosine phosphatase (PTP) 1B inhibitors based on sugar scaffolds, a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides was efficiently constructed via the modular and selective Cu(l)-catalyzed azide-alkyne 1,3-dipolar cycloaddtion (click chemistry). These glycoconjugates bearing alkyl chain length-varied bridges between the sugar and (hydroxy)benzoic moieties were identified as new PTP1B inhibitors with selectivity over T-Cell PTP (TCPTP), SH2-Containing PTP-1 (SHP-1), SHP-2 and Leukocyte Antigen-Related Tyrosine Phosphatase (LAR). Molecular docking study sequentially elaborated the plausible binding modes of the structurally diverse sugar-based inhibitors with PTP1B. (C) 2011 Elsevier Masson SAS. All rights reserved.

Type :

Publication

Dates :

Paru le 25 juin 2011

Informations complémentaires :

doi 10.1016/j.ejmech.2011.06.025